Endocannabinoid system of The Human Body

We all have surely heard of the transmitter systems operating within our bodies in school, for instance the sympathetic nervous system that helps us in our fight or flight responses. But only a small group of us have really got to know about the Endocannabinoid system (ECS) which was recently discovered. It is considered that the endocannabinoid system is great when one considers that its critical for almost every moment to moment operation that happens. ECS is responsible for regulating and controlling most of the body's critical functions like memory, learning, eating, drinking, emotional intelligence, sleeping patterns and routines, pain, bodily temperatures in different settings, inflammatory and immune responses.

An active endocannabinoid system is a complex cell signaling network. Its processing involves a combination of endocannabinoids, enzymes, and cannabinoid receptors that help regulate several functions in the human body.

Endocannabinoid system cb1 & cb2

How do we define Endocannabinoids? 

Endocannabinoids are naturally occurring, lipid-based neurotransmitters, also known as Endogenous Cannabinoids. Neurotransmitters are messengers in the body that help send signals between nerve endings and further, among cells. Endocannabinoids help our body in various ways by helping it smoothly perform its functions. They are produced by the body as and when necessary and this particular reason makes it difficult to understand what normal or typical levels are.

Two of the main endocannabinoids identified include:

  • Anandamide (AEA or arachidonoyl ethanolamide)
  • 2-archidonoyl glyerol (2-AG)

Experts believe there are additional endocannabinoids in the body, but their roles and functions are not definitively known yet.

What are the Endocannabinoid receptors?

Throughout our body, Cannabinoid receptors are present on the surface of each cell. They attach themselves to the receptors that send a signal or chemical message to the Endocannabinoid System to kick-start a response. They may attach themselves to CB1 or CB2 receptors, resulting differently depending on the location they are at in the body. 

The two primary cannabinoid receptors are present throughout the body:

Cannabinoid receptors

What are Enzymes?

The element in the whole process that is responsible for the breaking down of the endocannabinoids after the carrying out of the needed response of information is called an enzyme. The two primary enzymes responsible for this breaking down process are:

  • fatty acid amide hydrolase, which breaks down AEA
  • monoacylglycerol acid lipase, which breaks down 2-AG

How Does Medical Cannabis Work with the Endocannabinoid System?

The most common question while discussing or explaining the Endocannabinoid system, that comes up is - If every human body has its own Endocannabinoid System, then why does one need cannabinoids from outside? The answer to this is, simply, what happens when there is deficiency or lack of iron or protein or calcium in one's body? We add substitutes and supplements to level up the deficiency  and plan to maintain it as necessary. Similarly, if there is a supposed deficiency of cannabinoids in our body or the endocannabinoid system is not working properly, we will provide it with the necessities. 

As Cannabis Leaf Extracts contain naturally occurring plant-based compounds with similar definition and structures to the human body’s ECS, it makes it prevalent to understand that it will comparably function well. For example, THC can bind with CB1 receptors in the brain to mimic anandamide’s activity.

Also, intoxicating effects are not produced by CBD. It is believed by researchers and scientists that instead of binding directly with cannabinoid receptors, it is indirectly increasing one's cannabinoid levels in the body. Thus, CBD can be a source of multiple therapeutic benefits of the cannabis plant without the high. This fairly explains why and how this compound is becoming more and more popular.

The ECS is simply, the human body’s naturally occurring cannabis system. It is responsible for influencing a number of mind and body functions to best promote health and homeostasis. It all happens on a complete and holistic level. 

It is also advised and believed by many practitioners and researchers that giving Full Spectrum Cannabis Medicine will work in a much better way than giving isolates. Additionally, the interaction of all the compounds that are present in the cannabis plant with the ECS is known as The Entourage Effect. It basically explains that the complete effect or wholesome effect of all the compounds present together is better than individual isolates. 

Furthermore, Ayurveda is the best advocate that suggests and promotes the use of medical cannabis in its form that is whole, treating this medicine and all the compounds of it together as one complete ingredient.

Believing in the science of ayurveda and the high potential of this plant (also known as “Vijaya”) treating various conditions of the human body, Ananta Hemp Works brings a whole line of products under the brand name CannaEase based on the extract of the vijaya leaf. For more details and product information please visit https://hempworks.in/

1 comment


  • Abitha

    How Vijaya Extract help in Traeting indian patients?
    vijaya has been used since time immemorial to treat several disorders. However, in the recent past, due to legislative differences and some countries, people are once again beginning to notice the value of cannabis and begin to use them in conjunction with other therapies.


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